{"id":10997,"date":"2010-08-09T18:00:00","date_gmt":"2010-08-09T18:00:00","guid":{"rendered":""},"modified":"2010-08-09T18:00:00","modified_gmt":"2010-08-09T18:00:00","slug":"po-infarkto-sirdys-issigydys-pacios","status":"publish","type":"post","link":"https:\/\/www.pasveik.lt\/lt\/sveikatos-ir-medicinos-naujienos\/po-infarkto-sirdys-issigydys-pacios\/10997\/","title":{"rendered":"Po infarkto \u0161irdys i\u0161sigydys pa\u010dios"},"content":{"rendered":"
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Po penkeri\u0173 met\u0173 miokardo infarkt\u0105 <\/a>patyrusi\u0173 \u017emoni\u0173 \u0161irdys pa\u017eeistus savo audinius gal\u0117s atkurti pa\u010dios – toki\u0105 galimyb\u0119 suteiks JAV mokslinink\u0173 sukurta \u0161irdies raumens regeneravimo technologija.<\/div>\n<\/div>\n
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\u0160is revoliucinis pasiekimas gal\u0117s b\u016bti naudojamas ne tik \u0161irdies infarkto atvejais, bet ir tada, kai \u0161irdies raumens pakitimai atsiranda d\u0117l su pacient\u0173 am\u017eiumi susijusi\u0173 poky\u010di\u0173, skelbia „Telegraph.co.uk“.<\/div>\n
Naujasis \u0161irdies gydymo b\u016bdas primena kamienini\u0173 l\u0105steli\u0173 terapij\u0105, ta\u010diau, u\u017euot auginus naujas \u0161irdies skersaruo\u017eio raumens l\u0105steles laboratorin\u0117mis s\u0105lygomis ir v\u0117liau jas su\u0161vir\u0161kus jas pacientui, \u0161irdies audinio l\u0105stel\u0117s papras\u010diausiai perprogramuojamos.<\/div>\n
Pagrindin\u0117 problema, kylanti \u0161irdies miokarto infarkto atveju – tai, kad \u017euvus kardiomiocitams, \u0161irdies skersaruo\u017eio raumens l\u0105stel\u0117ms, j\u0173 nebe\u012fmanoma atkurti, o \u0161irdies jungiamojo audinio l\u0105stel\u0117s – fibroblastai – negali perimti j\u0173 funkcij\u0173, sakoma prane\u0161ime.<\/div>\n
Ta\u010diau Kalifornijos universiteto Gladstone\\’o instituto (JAV) profesoriaus Deepako Srivastavos vadovaujama mokslinink\u0173 grup\u0117 atrado b\u016bd\u0105, kaip fibroblastus galima perprogramuoti \u012f kardiomiocitus.<\/div>\n
Tai daroma l\u0117tai per stent\u0105 \u012f krauj\u0105 suleid\u017eiant tris med\u017eiagas, teigiama prane\u0161ime. Profesorius D. Srivastava mano, kad po \u0161ios proced\u016bros<\/a> \u0161irdies jungiamojo audinio l\u0105stel\u0117s reikiamoje vietoje gali perimti \u017euvusi\u0173 \u0161irdies raumens l\u0105steli\u0173 funkcijas jau po 2 savai\u010di\u0173.<\/div>\n
„I\u0161 prad\u017ei\u0173 mes tur\u0117jome i\u0161bandyti, ar \u0161ios poveikio priemon\u0117s gali transformuoti \u017emogaus fibroblastus \u012f \u0161irdies kontrakcin\u0119 funkcij\u0105 atliekant\u012f raumenin\u012f audin\u012f, o po to rasti b\u016bd\u0173, kaip saugiai \u012fterpti \u0161ias priemones \u012f koronarin\u0119 kraujotak\u0105, kad jos gal\u0117t\u0173 perprogramuoti fibroblastus, – sak\u0117 profesorius. – Manau, kad \u0161ioms priemon\u0117ms \u012fterpti gal\u0117t\u0173 b\u016bti naudojamas stentas, kur\u012f reik\u0117t\u0173 \u012fvesti \u012f koronarin\u0119 arterij\u0105. \u0160ios med\u017eiagos b\u016bt\u0173 i\u0161plautos i\u0161 stento ir aktyvuot\u0173 fibroblast\u0173 perprogramavim\u0105 per 1 – 2 savaites.“<\/div>\n
Pasak jo, nors tyr\u0117j\u0173 siekis per artimiausius 5 metus prad\u0117ti tokios technologijos<\/a> klinikinius tyrimus \u0161iuo metu atrodo ambicingas, ta\u010diau yra pagr\u012fstas.<\/div>\n
JAV mokslininkai nustat\u0117, kad \u0161irdies jungiamojo audinio l\u0105stel\u0117ms perprogramuoti \u012f veikian\u010dius kardiomiocitus pakanka 3 baltym\u0173 – Gata4, Mef2c ir Tbx5. Tai patvirtino atlikti bandymai su laboratorin\u0117mis pel\u0117mis. Pra\u0117jus vos vienai dienai, kai jie buvo suleisti \u012f peli\u0173 \u0161irdis, iki 20 proc. fibroblast\u0173 plakan\u010dioje \u0161irdyje tranformavosi \u012f kardiomiocit\u0173 funkcijas atliekan\u010dias l\u0105steles.<\/div>\n
Kalifornijos universiteto Gladstone\\’o instituto mokslinink\u0173 atradim\u0105 pristatantis straipsnis paskelbtas \u017eurnale „Cell“.<\/div>\n
Pasak profesoriaus D. Srivastavos, galimyb\u0117 perprogramuoti fibroblastus \u012f kardiomiocitus medicinoje atvers daug galimybi\u0173. Jis primin\u0117, kad pus\u0117 \u0161irdies l\u0105steli\u0173 yra fibroblastai, tod\u0117l galimyb\u0117 naudotis tokiu j\u0173 rezervu, paver\u010diant jas \u0161irdies raumens l\u0105stel\u0117mis, atveria „mil\u017eini\u0161k\u0105“ \u0161irdies regeneracijos perspektyv\u0105.<\/div>\n<\/div>\n

iMed<\/p>\n","protected":false},"excerpt":{"rendered":"

Po penkeri\u0173 met\u0173 miokardo infarkt\u0105 patyrusi\u0173 \u017emoni\u0173 \u0161irdys pa\u017eeistus savo audinius gal\u0117s atkurti pa\u010dios – toki\u0105 galimyb\u0119 suteiks JAV mokslinink\u0173 sukurta \u0161irdies raumens regeneravimo technologija.<\/div>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[27313],"tags":[2628,799,291,352],"site":[],"post_item_type":[27344],"class_list":["post-10997","post","type-post","status-publish","format-standard","hentry","category-gydymo-naujienos","tag-jungiamojo-audinio-lasteles","tag-lastelems","tag-naudojamas","tag-profesorius"],"acf":{"post_sites":false},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/10997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/comments?post=10997"}],"version-history":[{"count":0,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/10997\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media?parent=10997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/categories?post=10997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/tags?post=10997"},{"taxonomy":"site","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/site?post=10997"},{"taxonomy":"post_item_type","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/post_item_type?post=10997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}