{"id":11473,"date":"2010-03-30T18:00:00","date_gmt":"2010-03-30T18:00:00","guid":{"rendered":""},"modified":"2015-05-21T16:22:10","modified_gmt":"2015-05-21T16:22:10","slug":"del-klopidogrelio-ir-protonu-siurblio-inhibitoriu-omeprazoliu-saveikos","status":"publish","type":"post","link":"https:\/\/www.pasveik.lt\/lt\/sveikatos-ir-medicinos-naujienos\/del-klopidogrelio-ir-protonu-siurblio-inhibitoriu-omeprazoliu-saveikos\/11473\/","title":{"rendered":"D\u0117l klopidogrelio ir proton\u0173 siurblio inhibitori\u0173 (omeprazoli\u0173) s\u0105veikos"},"content":{"rendered":"<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">Europos vaist\u0173 agent\u016bros (toliau \u2013 EMA) \u017dmon\u0117ms skirt\u0173 vaistini\u0173 preparat\u0173 komitetas (toliau \u2013 CHMP) atnaujino \u012fsp\u0117jimus d\u0117l vaistini\u0173 preparat\u0173, kuri\u0173 sud\u0117tyje yra klopidogrelio<\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">I\u0161analizavusi naujus duomenimis apie galim\u0105 klopidogrelio<span style=\"font-family: 1Times New Roman\\'; font-size: 12pt;\"><sup><span style=\"font-family: Tahoma; font-size: 10pt;\">1<\/span><\/sup><\/span> ir <a href=\"https:\/\/pasveik.lt\/vaistai\/6;system;A02\">proton\u0173 siurblio inhi<\/a>bitori\u0173 (toliau \u2013 <span>\u00a0<\/span>PSI)<span style=\"font-family: Tahoma; font-size: 10pt;\"><sup>2 <\/sup><\/span>s\u0105veik\u0105, EMA rekomendavo pakoreguoti \u0161iuo metu esant\u012f \u012fsp\u0117jim\u0105 d\u0117l vaistini\u0173 preparat\u0173, kuri\u0173 sud\u0117tyje yra klopidogrelio ir proton\u0173 siurblio inhibitori\u0173,<span>\u00a0 <\/span>vartojimo kartu. <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">Klopidogrelis yra trombocit\u0173 agregacij\u0105 slopinantis vaistinis preparatas, vartojamas siekiant i\u0161vengti tromb\u0173 sukeliam\u0173 sutrikim\u0173, toki\u0173 kaip <a href=\"https:\/\/pasveik.lt\/lt\/ligos-ir-sindromai\/miokardo-infarktas\/4345\">miokardo infarktas<\/a> arba insultas. Patek\u0119s \u012f organizm\u0105, klopidogrelis, veikiant fermentui CYP2C19, tampa aktyvus. PSI yra <a href=\"https:\/\/pasveik.lt\/vaistai\/6;system;A02\">vaistiniai preparatai<\/a>, vartojami r\u0117mens bei skrand\u017eio op\u0173 gydymui, kuriuos galima \u012fsigyti be recepto. Kadangi <a href=\"https:\/\/pasveik.lt\/ligos-ir-sindromai\/remuo\/4527\">r\u0117muo<\/a> ir <a href=\"https:\/\/pasveik.lt\/ligos-ir-sindromai\/opalige\/4346\">skrand\u017eio opos <\/a>gali pasireik\u0161ti kaip klopidogrelio nepageidaujamas poveikis, pacientai, vartojantys klopidogrel\u012f, siekdami i\u0161vengti arba palengvinti \u0161iuos simptomus, da\u017enai vartoja PSI.<\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">Remdamasis steb\u0117jimo tyrim\u0173 publikacijomis pagal kurias PSI gali suma\u017einti klopidogrelio veiksmingum\u0105, slopinant jo suaktyvinim\u0105, CHMP 2009 m. gegu\u017e\u0117s m\u0117n. rekomendavo atnaujinti informacij\u0105 apie visus vaistinius preparatus, kuri\u0173 sud\u0117tyje yra klopidogrelio. Vadovaujantis \u0161ia informacija, klopidogrelis neturi b\u016bti vartojamas kartu su PSI, i\u0161skyrus b\u016btinus atvejus.<\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">CHMP susipa\u017eino su nauj\u0173 tyrim\u0173 rezultatais, i\u0161 kuri\u0173 keli suk\u0117l\u0117 abejoni\u0173 d\u0117l klopidogrelio ir PSI vaist\u0173 s\u0105veikos. Du tyrimai, u\u017ebaigti 2009 m. rugpj\u016b\u010dio m\u0117n. pabaigoje, nagrin\u0117jo omeprazolo poveik\u012f klopidogrelio aktyvios formos kiekiui kraujyje. \u0160i\u0173 tyrim\u0173 rezultatai patvirtino, kad omeprazolas gali suma\u017einti aktyvaus klopidogrelio kiek\u012f kraujo plazmoje ir taip susilpninti jo antitrombozin\u012f poveik\u012f. Taigi patvirtinama i\u0161vada, kad yra tarpusavio s\u0105veika tarp klopidogrelio bei omeprozolo ir ezomeprozolo.<\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">Atsi\u017evelgdama \u012f visus \u0161iuo metu turimus duomenis, CHMP ir Farmakologinio budrumo darbo grup\u0117 nusprend\u0117, kad n\u0117ra rimto pagrindo taikyti \u012fsp\u0117jimus d\u0117l s\u0105veikos kitiems PSI. \u012esp\u0117jimas visai PSI vaist\u0173 klasei d\u0117l s\u0105veikos su klopidogreliu buvo pakeistas \u012fsp\u0117jimu, pagal kur\u012f, klopidogrelio ir tik omeprazolo ir ezomeprazolo negalima vartoti kartu. CHMP taip pat rekomendavo informacij\u0105 apie \u0161iuos vaistinius preparatus papildyti dviej\u0173 neseniai atlikt\u0173 tyrim\u0173 d\u0117l klopidogrelio ir omeprazolo s\u0105veikos rezultatais.<\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">\u00a0 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\"><span style=\"font-family: 1Times New Roman\\'; font-size: 12pt;\"><sup><span style=\"font-family: Tahoma; font-size: 10pt;\">1<\/span><\/sup><\/span> Europos S\u0105jungoje yra prekiniu pavadinimu Plavix ir Iscover, taip pat yra generini\u0173 vaistini\u0173 <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\"><span>\u00a0 <\/span>preparat\u0173.<\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\"><sup>2 <\/sup><\/span>omeprazolas ir jo S-izomerai ezomeprazolas, lansoprazolas, pantoprazolas ir rabeprazolas. <\/span><\/p>\n<p style=\"margin: 0cm 0cm 0pt;\">\u00a0<\/p>\n<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">VVKT<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p style=\"margin: 0cm 0cm 0pt;\"><span style=\"font-family: Tahoma; font-size: 10pt;\">Europos vaist\u0173 agent\u016bros (toliau \u2013 EMA) \u017dmon\u0117ms skirt\u0173 vaistini\u0173 preparat\u0173 komitetas (toliau \u2013 CHMP) atnaujino \u012fsp\u0117jimus d\u0117l vaistini\u0173 preparat\u0173, kuri\u0173 sud\u0117tyje yra klopidogrelio<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[27313],"tags":[93,6678,141],"site":[],"post_item_type":[27344],"class_list":["post-11473","post","type-post","status-publish","format-standard","hentry","category-gydymo-naujienos","tag-infarktas","tag-informacija","tag-insultas"],"acf":{"post_sites":false},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/11473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/comments?post=11473"}],"version-history":[{"count":0,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/11473\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media?parent=11473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/categories?post=11473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/tags?post=11473"},{"taxonomy":"site","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/site?post=11473"},{"taxonomy":"post_item_type","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/post_item_type?post=11473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}