{"id":12428,"date":"2009-06-10T18:00:00","date_gmt":"2009-06-10T18:00:00","guid":{"rendered":""},"modified":"2009-06-10T18:00:00","modified_gmt":"2009-06-10T18:00:00","slug":"atskleista-apsaugos-pries-vezi-paslaptis","status":"publish","type":"post","link":"https:\/\/www.pasveik.lt\/lt\/sveikatos-ir-medicinos-naujienos\/atskleista-apsaugos-pries-vezi-paslaptis\/12428\/","title":{"rendered":"Atskleista apsaugos prie\u0161 v\u0117\u017e\u012f paslaptis"},"content":{"rendered":"<p style=\"text-align: justify\">Tyr\u0117jai atskleid\u0117 mechanizm\u0105, kurio d\u0117ka l\u0105stel\u0117s \u012fjungia ir i\u0161jungia p53 gen\u0105, atsaking\u0105 u\u017e augli\u0173 vystym\u0105si. Anot tyr\u0117j\u0173, \u0161is atradimas tur\u0117s labai didel\u0119 reik\u0161m\u0119 diagnozuojant bei gydant v\u0117\u017einius susirgimus. <\/p>\n<p>Tyrim\u0105 atliko Singap\u016bro ir Dundee universiteto mokslininkai. P53 genas atrastas prie\u0161 30 met\u0173. P53 atlieka gyvybi\u0161k\u0105 funkcij\u0105 \u017emogaus organizme. B\u016btent \u0161is genas pa\u017eeistoms l\u0105stel\u0117ms duoda komand\u0105 nusi\u017eudyti arba tuo metu, kai organizmas sutvarko pa\u017eeistas l\u0105steles, sustabdo \u0161i\u0173 l\u0105steli\u0173 dalijimosi proces\u0105. Pus\u0117 v\u0117\u017eini\u0173 susirgim\u0173 kyla d\u0117l p53 geno pa\u017eeidimo ar neveiklumo. Esant tokiai situacijai pa\u017eeistos l\u0105stel\u0117s gali laisvai dalytis ir formuoti auglius.<\/p>\n<p style=\"text-align: justify\">Paskutinio tyrimo metu mokslininkai panaudojo genetin\u012f triuk\u0105, kurio d\u0117ka \u012fjungus gen\u0105 p53 zebro \u017euvyt\u0117 \u0161vyt\u0117davo \u017ealiai. Tokiu b\u016bdu mokslininkai tyr\u0117 geno reguliavimo mechanizmus. Nustatyta, kad p53 genas ne tik atsakingas u\u017e stabilaus p53 baltymo gamyb\u0105, bet ir alternatyv\u0173 baltymo p53, \u017einomo kaip izoforma, genetin\u012f pakitim\u0105 &ndash; taip vadinam\u0105 &bdquo;valdymo jungikl\u012f&ldquo;. \u012eprastai zebra \u017euvel\u0117, turinti tok\u012f pat\u012f p53 gen\u0105 kaip \u017emon\u0117s, gali pakelti ma\u017eas radiacijos dozes, pa\u017eeid\u017eian\u010dias DNR. Tuomet p53 genas atstato padarytus pa\u017eeidimus. Ta\u010diau pa\u0161alinus izoformin\u012f jungikl\u012f nustatyta, kad organizmas neatlikdavo l\u0105steli\u0173 remonto darb\u0173 ir po radiacijos doz\u0117s \u017euvel\u0117s numirdavo. Tokiu b\u016bdu mokslininkams pavyko \u012frodyti, kad jungiklis vaidina pagrindin\u012f vaidmen\u012f \u012fjungiant p53 gen\u0105, inicijuojant\u012f l\u0105steli\u0173 atstatymo darbus. <br \/>\n&nbsp;<\/p>\n<p style=\"text-align: justify\">iMed<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tyr\u0117jai atskleid\u0117 mechanizm\u0105, kurio d\u0117ka l\u0105stel\u0117s \u012fjungia ir i\u0161jungia p53 gen\u0105, atsaking\u0105 u\u017e augli\u0173 vystym\u0105si. Anot tyr\u0117j\u0173, \u0161is atradimas tur\u0117s labai didel\u0119 reik\u0161m\u0119 diagnozuojant bei gydant v\u0117\u017einius susirgimus. <br \/>\n&nbsp;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[996],"site":[],"post_item_type":[27344],"class_list":["post-12428","post","type-post","status-publish","format-standard","hentry","tag-baltymo"],"acf":{"post_sites":false},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/12428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/comments?post=12428"}],"version-history":[{"count":0,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/12428\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media?parent=12428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/categories?post=12428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/tags?post=12428"},{"taxonomy":"site","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/site?post=12428"},{"taxonomy":"post_item_type","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/post_item_type?post=12428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}