{"id":7812,"date":"2014-04-08T15:13:40","date_gmt":"2014-04-08T15:13:40","guid":{"rendered":""},"modified":"2014-04-08T15:13:40","modified_gmt":"2014-04-08T15:13:40","slug":"osteoartrito-ir-gliukozamino-sulfato-rysys-gydant-pacientus","status":"publish","type":"post","link":"https:\/\/www.pasveik.lt\/lt\/naujausi-medicinos-straipsniai\/osteoartrito-ir-gliukozamino-sulfato-rysys-gydant-pacientus\/7812\/","title":{"rendered":"Osteoartrito ir gliukozamino sulfato ry\u0161ys gydant pacientus"},"content":{"rendered":"

\u00a0\u012evadas <\/strong><\/p>\n

Osteoartritas (OA) \u2013 labiausiai paplitusi degene\u00adracin\u0117 liga, pa\u017eeid\u017eianti s\u0105nari\u0173 strukt\u016br\u0105. Pagrindi\u00adn\u0117 OA prie\u017eastis \u2013 per didelis arba nuolatinis kr\u016b\u00advis, tenkantis s\u0105nariams: sunkus fizinis darbas, ilga\u00adlaik\u0117 nepatogi k\u016bno pad\u0117tis, buvusi s\u0105nario trauma, antsvoris (1). \u0160i liga vystosi laipsni\u0161kai ir pa\u017eeid\u017eia s\u0105nario kremzl\u0119 bei po ja esant\u012f subchondrin\u012f kau\u00adl\u0105 (2). D\u0117l toki\u0173 anatomini\u0173 s\u0105nario audini\u0173 poky\u00ad\u010di\u0173 sutrinka s\u0105nario funkcija (apribojamas judru\u00admas), atsiranda skausmas. Tradici\u0161kai osteoartroze sergantiems pacientams skausmui mal\u0161inti skiriama nesteroidini\u0173 vaist\u0173 nuo u\u017edegimo (NVNU), ta\u010diau j\u0173 vartojim\u0105 neretai riboja \u0161alutinio poveikio rei\u0161\u00adkiniai. NVNU nesustabdo s\u0105nari\u0173 kremzl\u0117se vyks\u00adtan\u010di\u0173 degeneracini\u0173 pakitim\u0173, tod\u0117l ie\u0161koma alter\u00adnatyvi\u0173 gydymo b\u016bd\u0173, nesukelian\u010di\u0173 toki\u0173 \u0161alutinio poveikio rei\u0161kini\u0173. Pastaruosius kelis de\u0161imtme\u010dius itin domimasi gliukozamino sulfatu, kuris, teigiama, suma\u017eina defektus, atsirandan\u010dius ankstyvojoje s\u0105\u00adnario kremzl\u0117s pa\u017eeidimo stadijoje.<\/p>\n

Etiologija <\/strong><\/p>\n

Nuolatinis \u017ealojantis mechaninis poveikis s\u0105na\u00adriams \u2013 viena pagrindini\u0173 prie\u017eas\u010di\u0173, turin\u010di\u0173 \u012ftakos OA i\u0161sivystyti. I\u0161oriniai veiksniai skatina chondro\u00adcit\u0173 katabolinius procesus ir kremzl\u0117s matrikso pa\u017eei\u00addim\u0105 (3).<\/p>\n

OA rizikos veiksniai:<\/p>\n

\u00b7 am\u017eius;<\/p>\n

\u00b7 nutukimas;<\/p>\n

\u00b7 traumos;<\/p>\n

\u00b7 genetiniai veiksniai;<\/p>\n

\u00b7 lytiniai hormonai;<\/p>\n

\u00b7 raumen\u0173 silpnumas;<\/p>\n

\u00b7 monotoni\u0161ki, pasi\u00adkartojantys judesiai (sunkus fizinis dar\u00adbas, nuolatinis s\u0105nario lankstymas);<\/p>\n

\u00b7 infekcijos;<\/p>\n

\u00b7 paveldimosios med\u017eia\u00adg\u0173 apykaitos ligos (alkaptonurija, hemochroma\u00adtoz\u0117, Wilsono liga);<\/p>\n

\u00b7 hemoglobinopatijos (talasemija, pjautuvini\u0173 l\u0105steli\u0173 anemija);<\/p>\n

\u00b7 neurologin\u0117s b\u016bkl\u0117s, veikian\u010dios s\u0105nar\u012f (sirin\u00adgomielija, nugaros smegen\u0173 d\u017ei\u016btis, diabetas);<\/p>\n

\u00b7 ortopedin\u0117s b\u016bkl\u0117s (\u012fgimtas klubo s\u0105nario i\u0161ni\u00adrimas, \u0161launikaulio galvut\u0117s epifiz\u0117s poslinkis);<\/p>\n

\u00b7 kaul\u0173 ligos (Pageto liga, nekraujagyslin\u0117 ne\u00adkroz\u0117).<\/p>\n

Kas vyksta s\u0105naryje sergant OA? <\/strong><\/p>\n

OA \u2013 l\u0117tai progresuojanti liga, kuriai b\u016bdinga nuolatinis s\u0105nari\u0173 kremzli\u0173 irimas ir pokremzlinio kaulo poky\u010diais (1 pav.<\/em>).<\/p>\n

\n","protected":false},"excerpt":{"rendered":"

Osteoartritas (OA) \u2013 labiausiai paplitusi degene\u00adracin\u0117 liga, pa\u017eeid\u017eianti s\u0105nari\u0173 strukt\u016br\u0105. Pagrindi\u00adn\u0117 OA prie\u017eastis \u2013 per didelis arba nuolatinis kr\u016b\u00advis, tenkantis s\u0105nariams: sunkus fizinis darbas, ilga\u00adlaik\u0117 nepatogi k\u016bno pad\u0117tis, buvusi s\u0105nario trauma, antsvoris (1). \u0160i liga vystosi laipsni\u0161kai ir pa\u017eeid\u017eia s\u0105nario kremzl\u0119 bei po ja esant\u012f subchondrin\u012f kau\u00adl\u0105 (2). D\u0117l toki\u0173 anatomini\u0173 s\u0105nario audini\u0173 poky\u00ad\u010di\u0173 sutrinka s\u0105nario funkcija (apribojamas judru\u00admas), atsiranda skausmas.<\/p>\n","protected":false},"author":1,"featured_media":7813,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[27313],"tags":[3758,689,3759,137,184,157,832,751,798,873,284,3760,1327,345,3500,727],"site":[],"post_item_type":[27345],"class_list":["post-7812","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gydymo-naujienos","tag-chondrocitai","tag-diagnostika","tag-gliukozamino-sulfatas","tag-ligonis","tag-maiste","tag-nutukimas","tag-nvnu","tag-placebo","tag-plazmos","tag-preparatas","tag-sanario","tag-sanario-kremzles","tag-skystis","tag-stadijoje","tag-sulfatas","tag-veiksmingas"],"acf":{"post_sites":false},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/7812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/comments?post=7812"}],"version-history":[{"count":0,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/7812\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media\/7813"}],"wp:attachment":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media?parent=7812"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/categories?post=7812"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/tags?post=7812"},{"taxonomy":"site","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/site?post=7812"},{"taxonomy":"post_item_type","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/post_item_type?post=7812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}