{"id":7970,"date":"2014-01-27T16:21:11","date_gmt":"2014-01-27T16:21:11","guid":{"rendered":""},"modified":"2014-01-27T16:21:11","modified_gmt":"2014-01-27T16:21:11","slug":"kokie-veiksniai-turi-itakos-motorinems-komplikacijoms-sergant-parkinsono-liga","status":"publish","type":"post","link":"https:\/\/www.pasveik.lt\/lt\/naujausi-medicinos-straipsniai\/kokie-veiksniai-turi-itakos-motorinems-komplikacijoms-sergant-parkinsono-liga\/7970\/","title":{"rendered":"Kokie veiksniai turi \u012ftakos motorin\u0117ms komplikacijoms sergant Parkinsono liga?"},"content":{"rendered":"<p style=\"text-align: justify;\">Kol kas dar n\u0117ra visi\u0161kai ai\u0161kios motorini\u0173 komplikacij\u0173, sergant <a href=\"https:\/\/pasveik.lt\/lt\/ligos-ir-sindromai\/parkinsono-liga\/53678\">Parkinsono liga<\/a> (PL), prie\u00ad\u017eastys ir mechanizmai. Motorini\u0173 komplikacij\u0173 i\u0161sivystym\u0105 gali lemti keletas veiksni\u0173: PL pra\u00add\u017eios am\u017eius, ligos eiga, lytis, pradinis gydymas ir galb\u016bt tam tikras genotipas. Tipi\u0161kam PL ser\u00adgan\u010diam ligoniui tikimyb\u0117, kad i\u0161sivystys moto\u00adrini\u0173 fliuktuacij\u0173 per 5 metus, yra 40 proc.<\/p>\n<p style=\"text-align: justify;\">Ispanijoje atliktoje studijoje PL susirg\u0119 ligo\u00adniai steb\u0117ti 10 met\u0173. Buvo vertinamas ligos pro\u00adgresavimas pagal unifikuot\u0105 Parkinsono ligos ver\u00adtinimo skal\u0119 (angl. <em>Unified Parkinson Disease Ra\u00adting Scale <\/em>\u2013 UPDRS) bei motorini\u0173 komplikaci\u00adj\u0173 atsiradimas (motorini\u0173 fliuktuacij\u0173, <em>nusid\u0117v\u0117\u00adjimo fenomeno<\/em>; su vaistais susijusi\u0173 diskinezij\u0173, \u012fskaitant ir <em>on-off <\/em>fenomen\u0105; eisenos sustingimas. Pagal am\u017ei\u0173 (&gt;58 met\u0173 ir &lt;58 met\u0173), pradin\u012f gy\u00addym\u0105 (levodopa, palyginti su visais kitais vais\u00adtais PL gydyti), lyt\u012f bei tremoro (ne)buvim\u0105 ligos prad\u017eioje tiriamieji suskirstyti \u012f atskiras grupes.<\/p>\n<p style=\"text-align: justify;\">Prad\u0117jus gydym\u0105, ligoni\u0173 b\u016bkl\u0117 po stabilaus laikotarpio pablog\u0117davo iki pradinio negalios ly\u00adgio per 3\u20135 metus. Pradinis gydymas (levodopa <em>vs. <\/em>kiti medikamentai) netur\u0117jo \u012ftakos ligos pro\u00adgresavimui. PL progresavimui \u012ftakos tur\u0117jo am\u00ad\u017eius ligos prad\u017eioje \u2013 vyresni\u0173 ligoni\u0173 grup\u0117je liga vyst\u0117si grei\u010diau.<\/p>\n<p style=\"text-align: justify;\">Baigiantis pirmajam ligos de\u0161imtme\u010diui, dau\u00adgeliui pacient\u0173 pasirei\u0161k\u0117 diskinezijos (91 proc.), motorin\u0117s fliuktuacijos (62 proc.) ir eisenos su\u00adstingimo fenomenas (68 proc.). Nustatytas ry\u00ad\u0161ys tarp kai kuri\u0173 pacient\u0173 charakteristik\u0173 ir mo\u00adtorini\u0173 komplikacij\u0173 atsiradimo po 5 met\u0173, bet \u0161ie skirtumai buvo nereik\u0161mingi pra\u0117jus 10 ligos met\u0173. Motorini\u0173 fliuktuacij\u0173 atsiradimas susij\u0119s su pradiniu gydymu \u2013 da\u017enesnis levodopos gru\u00adp\u0117je (\u0161ans\u0173 santykis (\u0160S) 3,87); diskinezij\u0173 i\u0161si\u00advystymas \u2013 su pradiniu gydymu (\u0160S 8,31), am\u017eiu\u00admi ligos prad\u017eioje \u2013 da\u017enesnis jaunesni\u0173 ligoni\u0173 grup\u0117je (\u0160S 0,9) bei lytimi \u2013 da\u017enesnis moter\u0173 grup\u0117je (\u0160S 12,87).<\/p>\n<p style=\"text-align: justify;\" align=\"right\"><em>Pareng\u0117 Karolina Noreikait\u0117 <\/em><\/p>\n<p style=\"text-align: justify;\"><strong>LITERAT\u016aRA <\/strong><\/p>\n<p style=\"text-align: justify;\">Garcia-Ruiz P.J. et al. What factors influence motor complications in par\u00adkinson disease? A 10-year prospective study. <em>Clinical Neuropharmacology<\/em>, 2012 Jan, 35 (1), 1\u20135.<\/p>\n<p style=\"text-align: justify;\">\u017durnalas \u201eInternistas\u201c<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kol kas dar n\u0117ra visi\u0161kai ai\u0161kios motorini\u0173 komplikacij\u0173, sergant Parkinsono liga (PL), prie\u00ad\u017eastys ir mechanizmai. Motorini\u0173 komplikacij\u0173 i\u0161sivystym\u0105 gali lemti keletas veiksni\u0173: PL pra\u00add\u017eios am\u017eius, ligos eiga, lytis, pradinis gydymas ir galb\u016bt tam tikras genotipas. Tipi\u0161kam PL ser\u00adgan\u010diam ligoniui tikimyb\u0117, kad i\u0161sivystys moto\u00adrini\u0173 fliuktuacij\u0173 per 5 metus, yra 40 proc.<\/p>\n","protected":false},"author":1,"featured_media":7971,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[27313],"tags":[3543,2934],"site":[],"post_item_type":[27345],"class_list":["post-7970","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gydymo-naujienos","tag-levodopa","tag-ligos-pradzioje"],"acf":{"post_sites":false},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/7970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/comments?post=7970"}],"version-history":[{"count":0,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/posts\/7970\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media\/7971"}],"wp:attachment":[{"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/media?parent=7970"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/categories?post=7970"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/tags?post=7970"},{"taxonomy":"site","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/site?post=7970"},{"taxonomy":"post_item_type","embeddable":true,"href":"https:\/\/www.pasveik.lt\/lt\/wp-json\/wp\/v2\/post_item_type?post=7970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}